Biochemistry Lecture Notes

Introduction, Review of Biomolecules; Ch.1,2

Water, pH and dissociation; Ch. 3

Biomolecules: Amino Acids and Peptides; Ch. 4,5

Biomolecules: Peptides and Proteins; Ch. 5,6

Higher Order Protein Structures; Ch. 6

Protein Binding Phenomenon; lecture

Myoglobin and Hemoglobin; Ch. 7

Immunoglobulins as binding proteins ; Ch. 59

Protein Mutations and Disease; lecture

Nucleotide Structure; Ch. 35

DNA structure and properties; Ch. 37

RNA structure and properties; Ch. 37

DNA organization and replication; Ch. 38

Transcription and RNA processing; Ch. 39

Control of Transcription-procaryotes; Ch. 41

Protein Synthesis and the Genetic Code; Ch. 40

Synthesis of membrane proteins; Ch. 43

Molecular tools of genetic diagnosis; Ch 42

Enzymes; Ch. 8,10

Enzyme Kinetics; Ch. 9

Regulation of Enzyme activity; Ch. 11

Enzyme Cascades – Blood Clotting; Ch. 59

Muscle and cytoskeleton; Ch. 58

Overview of metabolism; Ch. 15,16,17

Bioenergetics; Ch. 12

Glycolysis; Ch. 19

Citric Acid Cycle, Pyruvate dehydrog; Ch. 18

Citric Acid Cycle and anaplerosis; Ch. 18

Electron transport; Ch. 13,14 Extra Slides for 35

Oxidative phosphorylation; Ch. 14

Mitochondria,energy, citric acid cycle; Ch.13,14

Glycogen metabolism and control; Ch. 20

Gluconeogenesis; Ch. 21

Hormonal Regulation: glycolysis/gluconeo; Ch. 51

Pentose Phosphate pathway; Ch. 22

Sugar catabolism and biosynthesis; Ch. 22

Clinical Correlation- Type-II diabetes

Complex Carbohydrates; Ch. 56

Fatty Acid Biosynthesis; Ch. 23

Fatty Acid Oxidation; Ch. 24

Clinical Correlation- Hyperlipidemia

Eicosanoid metabolism; Ch. 25

Membrane lipid biosynthesis; Ch. 26

Cholesterol and bile acid metabolism; Ch 28

Digestion and Absorption; Ch 55

Lipid transport and storage; Ch. 27

Lipid-soluble vitamins; Ch 53

Metabolic Integration/Nutrition; Ch. 29, 54

Water-soluble vitamins I; Ch. 52

Clinical Correlation - angina/folate

Water-soluble vitamins II; Ch. 52

Xenobiotic metabolism; Ch 61

Biosynthesis of amino acids; Ch 30

Nitrogen metabolism; Ch. 31

Specialized amino acids/heme biosynth;Ch. 33,34; Slides w/ Text

Purine metabolism; Ch. 36

Pyrimidine metabolism; Ch. 36

Membrane bilayer properties; Ch 43

Membrane transport; Ch. 43

Membrane receptors; G-proteins; Ch. 44

Cancer and Oncogenes; Ch 62

Growth and Differentiation; Ch 62

Biochemical and genetic basis of disease; Ch 63